5). tumor-suppressive microRNA, miR-34a, inside a p53-reliant manner, resulting in inhibition of Notch-1 manifestation. Consequently, decreased Notch-1 manifestation advertised apoptosis through significant down-regulation from the nuclear factor-B pathway, producing a radiosensitizing influence on NSCLC cells. Irradiation-induced epithelial-mesenchymal transition was notably attenuated in the current presence of rhamnetin and cirsiliol also. Furthermore, an xenograft mouse model … Continue reading 5)